1. Signaling Pathways
  2. Immunology/Inflammation
  3. Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

Salt-inducible Kinases (SIK) are a family of related serine-threonine kinases. In cultured adrenocortical cells, SIK1 is rapidly but transiently induced by adrenocorticotropin (ACTH) treatment, suggesting that it contributes to ACTH-mediated induction of steroidogenic enzymes. SIK2 is found in adipocytes and phosphorylates a specific serine residue. Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex in adipocytes.

Salt-inducible Kinase (SIK) 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-15776
    HG-9-91-01 Inhibitor 98.17%
    HG-9-91-01 是一种有效,选择性的盐诱导型激酶 (SIK) 抑制剂,作用于 SIK1SIK2SIK3IC50 分别为 0.92 nM,6.6 nM 和 9.6 nM。
  • HY-101147
    YKL-05-099 Inhibitor 99.76%
    YKL-05-099 是一种盐诱导型激酶 (SIK) 探针。YKL-05-099 作用于SIK1SIK3,IC50 分别约为 10 和 30 nM。YKL-05-099 抑制 SIK2 的活性稍低,IC50 值为 40 nM。
  • HY-120856
    ARN-3236 Inhibitor 98.12%
    ARN-3236 是具有口服活性的盐诱导激酶2 (SIK2) 的选择性抑制剂,其对 SIK2、SIK1 和 SIK3 的 IC50 值分别为 <1 nM、21.63 nM 和 6.63.nM。具有抗肿瘤活性。
Isoform Specific Products

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