1. Immunology/Inflammation
  2. Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

Salt-inducible Kinases (SIK) are a family of related serine-threonine kinases。 In cultured adrenocortical cells, SIK1 is rapidly but transiently induced by adrenocorticotropin (ACTH) treatment, suggesting that it contributes to ACTH-mediated induction of steroidogenic enzymes。 SIK2 is found in adipocytes and phosphorylates a specific serine residue in insulin receptor substrate-1。 Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex and insulin signaling in adipocytes。

Salt-inducible Kinase (SIK) 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-15776
    HG-9-91-01 Inhibitor 98.17%
    HG-9-91-01 是一种有效,选择性的盐诱导型激酶 (SIK) 抑制剂,作用于 SIK1SIK2SIK3IC50 分别为 0.92 nM,6.6 nM 和 9.6 nM。
  • HY-101147
    YKL-05-099 Inhibitor 99.76%
    YKL-05-099是一种盐诱导型激酶 (SIK) 探针; 抑制SIK2的IC50值为40 nM。
  • HY-120856
    ARN-3236 Inhibitor 98.12%
    ARN-3236 是具有口服活性的盐诱导激酶2 (SIK2) (IC50 <1 nM) 的选择性抑制剂,具有抑制体内外卵巢癌细胞生长以及增加癌细胞对紫杉醇敏感度的活性。
Isoform Specific Products

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