1. Signaling Pathways
  2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)

NOD-like Receptor (NLR)

Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

NOD-like Receptor (NLR) 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-12815A
    MCC950 sodium Inhibitor 99.43%
    MCC950 sodium是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的 IC50 分别为 7.5 nM 和 8.1 nM。
  • HY-12815
    MCC950 Inhibitor >98.0%
    MCC950 是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的IC50 分别为 7.5 nM 和 8.1 nM。
  • HY-103666
    CY-09 Inhibitor >98.0%
    CY-09 是 NLRP3 的抑制剂。
  • HY-100691
    NOD-IN-1 Inhibitor 98.99%
    NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂,IC50 值分别为 5.74 μM 和 6.45 μM。
  • HY-101868
    INF39 Inhibitor 99.61%
    INF39 是不可逆的,没有细胞毒性的NLRP3 抑制剂。
  • HY-17629
    Dapansutrile Inhibitor >98.0%
    Dapansutrile (OLT1177)是有效,选择性和有口服活性的 NLRP3 炎性小体抑制剂。 具有抗炎,镇痛活性。
  • HY-111815
    N4-Acetylcytidine triphosphate Activator
    N4-Acetylcytidine triphosphate 是一种内源性核苷代谢物,源于 tRNA 的降解,可通过诱导 HMGB1 的表达,启动和激活 NLRP3 炎症。
  • HY-N0139
    Troxerutin Inhibitor 98.05%
    Troxerutin 也被称为维生素 P4,是天然生物类黄酮芦丁的三羟乙基化衍生物,其可抑制活性氧 (ROS) 的产生并抑制 ER 应激介导的 NOD 活化。
  • HY-18639
    Nodinitib-1 Inhibitor >98.0%
    Nodinitib-1 (ML130;CID-1088438)是NOD1抑制剂,IC50值为0.56 μM。
  • HY-16059
    Arglabin Inhibitor 99.17%
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

新火彩票平台 大福彩票 金福彩票平台 网易彩票 印象彩票平台 网易彩票 平安彩票 8888彩票平台 完美彩票 平安彩票