1. GPCR/G Protein
    Neuronal Signaling
  2. Imidazoline Receptor

Imidazoline Receptor

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Imidazoline Receptor 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-101238
    Agmatine sulfate Agonist >98.0%
    Agmatine sulfate在多个靶点上发挥调节作用,如神经递质系统,离子通道,一氧化氮合成。它是 imidazoline receptor 的内源性激动剂和 NO synthase 抑制剂。
  • HY-N0543
    Allantoin Agonist 98.36%
    Allantoin是促进皮肤健康,刺激新鲜健康组织生长的皮肤调理剂。
  • HY-B0374
    Moxonidine Agonist 99.91%
    Moxonidine(BDF5895)是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
  • HY-B0374A
    Moxonidine hydrochloride Agonist
    Moxonidine(BDF5895)盐酸盐是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
  • HY-100179
    CR4056 Agonist 98.32%
    CR4056 是一个选择性的人重组 MAO-A 抑制剂,其 IC50 值为 202.7 nM。 CR4056 也是咪唑啉-2 受体 (I2R) 的配体,其 IC50 值为 596 nM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

265彩票平台 七匹狼彩票平台 炫乐彩票平台 6169彩票平台 世纪彩票平台 新优彩票平台 v8彩票平台 众盈彩票平台 kk彩票平台 九龙彩票平台