1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK

IRAK

Interleukin-1 receptor-associated kinase (IRAK) is first described as a signal transducer for the proinflammatory cytokine IL-1 and is later implicated in signal transduction of other members of the Toll-like receptor (TLR)/IL-1R family. Four different IRAK-like molecules have been identified: two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. All IRAKs mediate activation of NF-κB and MAPK pathways. IRAKs are protein kinases involved in signalling innate immune responses from TLRs. After TLR-4 and TLR-2 recognize pathogen-associated molecular patterns, such as LPS and peptidoglycan, all IRAK members form multimeric receptor complexes.

IRAKs are essential signaling intermediates in the TLR/IL-1R pathway to both IKK and MAPKs activation. These two pathways are central to the activation of several transcription factors, including NF-κB and AP-1, which contribute to the establishment of an immune response.

IRAK 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-13329
    IRAK-1-4 Inhibitor I Inhibitor 98.49%
    IRAK-1-4 Inhibitor I 是 IRAK1/4 抑制剂,IC50 分别为 0.2 μM 和 0.3 μM。
  • HY-19836
    PF06650833 Inhibitor 98.68%
    PF06650833 是一种白细胞介素-1受体相关激酶-4 (IRAK4) 的抑制剂,用于效治疗类风湿性关节炎、红斑狼疮和淋巴瘤等疾病。
  • HY-109585
    CA-4948 Inhibitor 98.44%
    CA-4948 是一种有选择性且有效的 IRAK4 抑制剂。
  • HY-N0039
    Ginsenoside Rb1 Inhibitor >98.0%
    Ginsenoside Rb1 是中药 Panax ginseng 的成分。Ginsenoside 抑制 Na+, K+-ATPase 活性,IC50 为 6.3±1.0 μM。Ginsenoside Rb1 也抑制 IRAK-1 激活及 NF-κB p65 的磷酸化。
  • HY-101922
    IRAK4-IN-1 Inhibitor 99.01%
    IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂,IC50 为 7 nM。
  • HY-111101
    AZ1495 Inhibitor 99.83%
    AZ1495 (compound 28) 是具有口服活性的,白介素-1受体相关激酶 4 (IRAK4) 的抑制剂,其对 IRAK4 和 IRAK1 的 IC50 值分别为 5 nM 和 23 nM。具有治疗突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 的活性。
  • HY-13275
    IRAK inhibitor 1 Inhibitor 99.47%
    IRAK inhibitor 1 是一种有效的 IRAK-4 抑制剂,IC50 为 216 nM,微弱抑制 JNK-1 和 JNK-2,IC50 分别为 3.801 μM 和 >10 μM。
  • HY-13276
    IRAK inhibitor 2 Inhibitor
    IRAK inhibitor 2是白细胞介素-1受体相关激酶4(IRAK-4)抑制剂。
  • HY-13280
    IRAK inhibitor 6 Inhibitor 99.75%
    IRAK inhibitor 6 是一种有效的白细胞介素-1受体相关激酶-4 (interleukin-1 receptor associated kinase 4) 的抑制剂,IC50 值为 160 nM。
  • HY-13278A
    IRAK inhibitor 4 trans Inhibitor 99.50%
    IRAK inhibitor 4 (trans)是IRAK inhibitor 4的trans形式,IRAK inhibitor 4是IRAK4的有效抑制剂。
  • HY-13278
    IRAK inhibitor 4 Inhibitor 98.05%
    IRAK inhibitor 4 是白细胞介素-1 受体相关激酶-4 (IRAK4) 的抑制剂。
  • HY-13277
    IRAK inhibitor 3 Modulator
    IRAK inhibitor 3 是一种白细胞介素-1受体相关激酶 (IRAK) 调节剂,详细信息请参考专利 WO 2008030579 A2。
Isoform Specific Products

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