1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Eukaryotic Initiation Factor (eIF) 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-13251
    Silvestrol Inhibitor 98.00%
    Silvestrol是从Aglaia foveolata的果实和枝条中分离的真核翻译起始因子 (eIF4A) 抑制剂。
  • HY-19831
    4EGI-1 Inhibitor >98.0%
    4EGI-1 是一种 eIF4E/eIF4G 相互作用抑制剂,抑制 eIF4E 结合,Kd 值为 25 μM。
  • HY-112654
    GCN2iB Inhibitor 99.81%
    GCN2iB 是具有 ATP 竞争性的、一种丝氨酸/苏氨酸蛋白激酶 ——压力应答激酶 (GCN2) 的抑制剂,其 IC50 值为 2.4 nM。
  • HY-14427
    4E1RCat Inhibitor >98.0%
    4E1RCat 是一种 cap 依赖性翻译抑制剂,能够抑制 eIF4E:eIF4GI 相互作用,IC50 值约为 4 μM。
  • HY-100733
    4E2RCat Inhibitor >98.0%
    4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5 μM。
  • HY-119240
    CCT020312 98.56%
    CCT020312能提供有效的、具有真核起始因子 2 激酶 3 (EIF2AK3) 选择性的增值控制,同时也是 RNA 样内质网激酶 (PERK) 的激动剂。
  • HY-101785
    eIF4A3-IN-2 Inhibitor
    eIF4A3-IN-2是高度选择性,非竞争型的真核起始因子4A-3 (eIF4A3)抑制剂,IC50 为110 nM。
  • HY-16366
    Briciclib Inhibitor 99.15%
    Briciclib 是一种可溶于水的 ON 013100 衍生物,具有靶作用于 eIF4E 对抗固体肿瘤的潜力。
  • HY-15359
    Episilvestrol Inhibitor 99.85%
    Episilvestrol 是 silvestrol 的衍生物,从 Aglaia silvestris 中分到,能够抑制 eIF4A 靶作用的转录过程。
  • HY-19560
    SBI-0640756 Inhibitor >98.0%
    SBI-0640756 (SBI-756) 是一种溶于水的 eIF4G1 抑制剂,能够破坏 eIF4F 复合体。
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