1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor

Ephrin Receptor

Ephrin receptors (Ephs) are a group of receptors that are activated in response to binding ephrin. Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Ephs and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/epherin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer. The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development.

Ephrin Receptor 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-18007
    ALW-II-41-27 Inhibitor 99.38%
    ALW-II-41-27是 Eph 家族酪氨酸激酶抑制剂,抑制Eph2的 IC50为11 nM。
  • HY-13314
    Tesevatinib Inhibitor 99.21%
    Tesevatinib (XL-647) 是口服可用的多靶点酪氨酸激酶抑制剂; 抑制EGFRErbB2KDRFlt4EphB4 激酶活性的 IC50 值分别为 0.3,16,1.5,8.7,和1.4 nM。
  • HY-13258
    NVP-BHG712 isomer 99.51%
    NVP-BHG712 isomer,是NVP-BHG712 的位置异构体,与EPHA2和EPHB4显示保守非键结合。
  • HY-16265
    JI-101 Inhibitor 99.95%
    JI-101是有口服活性的有抗癌活性的多靶点激酶抑制剂,可抑制 VEGFR2PDGFRβEphB4
Isoform Specific Products

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