1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. EAAT2

EAAT2

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses。 An increase in EAAT2 protein expression and function may provide a means to prevent insufficient glutamate reuptake and consequently reduce neuronal damage。

The glial glutamate transporter EAAT2 plays a major role in glutamate clearance. EAAT2 can be upregulated by transcriptional or translational activation.EAAT2 is a potential target for the prevention of excitotoxicity.

EAAT2 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-12741
    LDN-212320 Activator
    LDN-212320(OSU-0212320)是谷氨酸转运体EAAT2激动剂,在<5uM浓度下能增强EAAT2水平超过6倍。
  • HY-114381
    GT 949 Agonist
    GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂,EC50 为 0.26 nM。
  • HY-107523
    WAY-213613 Inhibitor
    WAY-213613 是一种有效、选择性的 EAAT2 抑制剂 (IC50,85 nM),对其选择性是对人 EAAT1 和 EAAT3 的 59 和 45 倍;抑制大鼠皮质突出体对谷氨酸的摄取。
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