1. Signaling Pathways
  2. GPCR/G Protein
  3. Angiotensin Receptor

Angiotensin Receptor

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor 相关产品 (56):

Cat. No. Product Name Effect Purity
  • HY-13948
    Angiotensin II human Modulator 99.96%
    Angiotensin II human是作用于 AT1 AT2 受体的血管收缩剂。
  • HY-17512
    Losartan Antagonist 99.24%
    Losartan 是血管紧张素II受体拮抗剂,与血管紧张素II竞争性结合AT1受体,IC50为20 nM。
  • HY-15778
    AVE 0991 Agonist 99.92%
    AVE 0991是非多肽,有口服活性的血管紧张素-(1-7)受体激动剂,IC50 为21 nM。
  • HY-13955
    Telmisartan Antagonist 99.96%
    Telmisartan 是一种有效的血管紧张素II 1型受体 (angiotensin II type 1 receptor) 拮抗剂,能够抑制其活性,IC50 值为 9.2 nM。
  • HY-12403
    Angiotensin 1-7 Inhibitor 99.61%
    Angiotensin (1-7) 抑制纯化的犬血管紧张素转换酶 (ACE) 活性,IC50 为 0.65 μM。
  • HY-114412
    TD-0212 Antagonist
    TD-0212 (compound 35) 是一种具有口服活性的、血管紧张素II型1受体 AT1 和脑啡肽酶 (NEP)的双抑制剂,其对 AT1pKi 值为 8.9, 对 NEP 的pIC50值为9.2。
  • HY-114161A
    H-Val-Pro-Pro-OH TFA Inhibitor >98.0%
    H-Val-Pro-Pro-OH (TFA),是牛奶来源的脯氨酸肽衍生物,是血管紧张素 I 转化酶 (ACE) 的抑制剂,其IC50 为 9 μM.
  • HY-114161
    H-Val-Pro-Pro-OH Inhibitor
    H-Val-Pro-Pro-OH,是牛奶来源的脯氨酸肽衍生物,是血管紧张素 I 转化酶 (ACE) 的抑制剂,其IC50 为 9 μM。
  • HY-P0216
    A 779 Antagonist >98.0%
    A 779 是G蛋白偶联受体Mas的有效拮抗剂,Mas受体为一种Ang1-7 receptor,区别于传统的AngII。
  • HY-17512A
    Losartan potassium Antagonist 99.91%
    Losartan potassium是血管紧张素II受体1型 (AT1)拮抗剂,与血管紧张素II与AT1的结合竞争,IC50为20 nM。
  • HY-B0195
    Tranilast Inhibitor 99.60%
  • HY-10259A
    PD 123319 ditrifluoroacetate Antagonist 99.76%
    PD 123319 ditrifluoroacetate 是一种有效的,选择性的 AT2 angiotensin II receptor 拮抗剂,IC50 值为 34 nM。
  • HY-18204
    Valsartan Antagonist 99.35%
    Valsarta (CGP-48933) 是用于治疗高血压和心力衰竭的血管紧张素II受体拮抗剂。
  • HY-18204A
    LCZ696 Inhibitor 99.96%
  • HY-17004
    Olmesartan Antagonist 99.01%
    Olmesartan 是血管紧张素II受体 (AT1R) 拮抗剂,常用于治疗高血压。
  • HY-13106
    Olodanrigan Antagonist 99.29%
    Olodanrigan (EMA401) 是一个高选择性的AT2R拮抗剂,能够抑制p38和p42/p44 MAPK激活引起的AngII/AT2R的增加,能够抑制DRG神经元兴奋过度。
  • HY-12405
    CGP-42112 Antagonist 98.82%
  • HY-B0205
    Candesartan Antagonist 98.34%
    Candesartan是血管紧张素II受体拮抗剂,IC50为0.26 nM。
  • HY-B0780
    Fimasartan Antagonist 98.77%
  • HY-B0202
    Irbesartan Antagonist 99.79%
    Irbesartan是1型血管紧张素II(AT1)受体拮抗剂,IC50为1.3 nM。
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