NSC 185058 

目录号: HY-125169
产品使用指南

NSC 185058 是一种 ATG4B 抑制剂。NSC185058 显著减弱自噬 (autophagic) 活性。

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NSC 185058 Chemical Structure

NSC 185058 Chemical Structure

CAS No. : 39122-38-8

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Description

NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].

IC50 & Target

Autophagy[1]

In Vitro

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6453 mL 23.2266 mL 46.4533 mL
5 mM 0.9291 mL 4.6453 mL 9.2907 mL
10 mM 0.4645 mL 2.3227 mL 4.6453 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • [1].

Molecular Weight

215.27

Formula

C₁₁H₉N₃S

CAS No.

39122-38-8

SMILES

S=C(C1=NC=CC=C1)NC2=NC=CC=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
NSC 185058
目录号:
HY-125169
需求量:

NSC 185058

Cat。 No。: HY-125169

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